Longevity
Aging Skin Reassigns Gene Regulators Toward Inflammation
Mouse research maps how BMAL1 and YAP shift from epidermal identity genes toward inflammatory enhancers as skin ages.
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Longevity
Longevity
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Longevity
A Nanoparticle Study Turns Senescence Against Liver Fibrosis
A preclinical nanomedicine study treats cellular senescence as a targeted, temporary tool for loosening fibrotic liver tissue and…
Longevity
AI Tissue Clocks Map How Organs Age at Different Speeds
A new AI analysis of human histology maps tissue-specific aging signatures while showing why biological age is not…
Longevity
Exercise Study Maps an Adiponectin Route in Ovarian Aging
Human associations and mouse experiments point to adiponectin-related signaling as a possible link between physical activity and ovarian…
Longevity
A Mitochondria-to-Lysosome Signal Extends Lifespan in Worms
New worm research links mitochondrial stress to a lysosomal protein-cleanup response, revealing a specific pathway that extended lifespan…
Longevity
Frailty Can Signal Risk Before Chronic Disease Appears
A large prospective analysis finds that frailty can identify elevated long-term risk even among middle-aged adults initially free…
Longevity
How Inflammation Can Age the Intestine’s Stem Cells
New mouse and organoid research connects inflammatory TNFR1 signaling to impaired fatty-acid metabolism in aging intestinal stem cells.
Longevity
Blood Stem Cells Do Not Age on a Single Track
Two new studies map how distinct blood stem-cell states and a changing bone-marrow niche can shape age-related clonal…
Longevity
A 13-Year Bat Rewrites a Species’ Longevity Record
A long-running Panama field study more than doubles one tropical bat’s longevity record, while leaving its age-related telomere…