Longevity
Epigenetic Clocks Can Move Without Proving Slower Aging
A 51-study human analysis finds some DNA-methylation clocks respond consistently to interventions, but biomarker movement is not proof…
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Longevity
Longevity
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Longevity
Supercentenarians’ Killer T Cells Point to Immune Adaptation
A human immune-profiling study finds rare cytotoxic CD4 T cells expand in centenarians and supercentenarians, suggesting adaptation without…
Longevity
Healthy Centenarians Reveal an Immune-Genetics Filter
A human genetics study finds six HLA alleles were less frequent among cognitively healthy Dutch centenarians, revealing immune…
Longevity
Aging Skin Reassigns Gene Regulators Toward Inflammation
Mouse research maps how BMAL1 and YAP shift from epidermal identity genes toward inflammatory enhancers as skin ages.
Longevity
A Nanoparticle Study Turns Senescence Against Liver Fibrosis
A preclinical nanomedicine study treats cellular senescence as a targeted, temporary tool for loosening fibrotic liver tissue and…
Longevity
AI Tissue Clocks Map How Organs Age at Different Speeds
A new AI analysis of human histology maps tissue-specific aging signatures while showing why biological age is not…
Longevity
Exercise Study Maps an Adiponectin Route in Ovarian Aging
Human associations and mouse experiments point to adiponectin-related signaling as a possible link between physical activity and ovarian…
Longevity
A Mitochondria-to-Lysosome Signal Extends Lifespan in Worms
New worm research links mitochondrial stress to a lysosomal protein-cleanup response, revealing a specific pathway that extended lifespan…
Longevity
Frailty Can Signal Risk Before Chronic Disease Appears
A large prospective analysis finds that frailty can identify elevated long-term risk even among middle-aged adults initially free…